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3-fluoro-5-morpholin-4-yl-N-[3-(2-pyridin-4-ylethyl)-1H-indol-5-yl]benzamide
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
3-fluoro-5-morpholin-4-yl-N-[3-(2-pyridin‑4‑ylethyl)‑1H‑indol‑5‑yl]benzamide is an experimental small molecule compound belonging to the phenylmorpholine class. It has been studied as a potential inhibitor of mitogen‐activated protein kinase 14 (MAPK14, also known as p38α MAP kinase), with reported in vitro activity (IC50 ~630 nM). There are no approved indications or clinical trials beyond preclinical/experimental status, and it is not marketed for any disease[1][7]. The compound’s mechanism of action involves inhibition of MAPK14, a kinase implicated in inflammatory and proliferative signaling pathways.
- Other names
- 3-fluoro-5-(morpholin-4-yl)-N-{3-[2-(pyridin-4-yl)ethyl]-1H-indol-5-yl}benzamide3-fluoro-5-morpholinyl-N-[3-(2-pyridinylethyl)-1H-indolyl]benzamide
02
Targets
MAPK14 (p38 mitogen-activated protein kinase alpha)
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